Cerca Articoli

Alvorlig kritik, påbud og advarsel til Region Hovedstaden efter to sikkerhedsbrud

Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast

• Otx2 binds to the promoter/enhancer region of Oct4, Sox2, and Nanog in ESCs and EpiSCs • Otx2 binding to the Nanog promoter helps maintain the integrity of ESC compartments • Loss of this Otx2-binding site induces primed-like features in ESCs • Otx2 regulation of Nanog contributes to ICM differentiation of the epiblast Mouse embryonic stem cells (ESCs) and the inner cell mass (ICM)-derived epiblast exhibit naive pluripotency. ESC-derived epiblast stem cells (EpiSCs) and the postimplantation epiblast exhibit primed pluripotency. Although core pluripotency factors are well-characterized, additional regulators, including Otx2, recently have been shown to function during the transition from naive to primed pluripotency. Here we uncover a role for Otx2 in the control of the naive pluripotent state. We analyzed Otx2-binding activity in ESCs and EpiSCs and identified Nanog, Oct4, and Sox2 as direct targets. To unravel the Otx2 transcriptional network, we targeted the strongest Otx2-binding site in the Nanog promoter, finding that this site modulates the size of specific ESC-subtype compartments in cultured cells and promotes Nanog expression in vivo, predisposing ICM differentiation to epiblast. Otx2-mediated Nanog regulation thus contributes to the integrity of the ESC state and cell lineage specification in preimplantation development.

Toscana: ecco la nuova giunta regionale

Presentata dal presidente Enrico Rossi in Consiglio region! ale La composizione della nuova giunta regionale

MEPs speak out in favour of more regional cooperation in the Black Sea region and the South Caucasus

The European Parliament adopted two reports, calling for more regional cooperation in the Black Sea and South Caucasus regions. In both areas, the House stressed the importance both of democratic principles and human rights and of the necessity to improve economic and trade relations, especially regarding energy supplies.

Therapeutic antibody MNAC13

Top view of the antigen binding region of the MNAC13 monoclonal antibody: when MNAC13 binds the TrkA receptor, it prevents it from being activated by nerve growth factor.

Strong quake buries children in East Africa

A powerful earthquake struck the region around Lake Tanganyika in East Africa on Monday, collapsing dozens of homes and burying children in the rubble.

DARFUR: TALKS PROCEED IN NIGERIA, CLASHES CONTINUE IN REGION

Darfur Children face malnutrition in Chad

Russia: Fonte Sanità indica oltre 200 morti nella scuola

Russian President Vladimir Putin has ordered the closure of the borders of the North Ossetia region after a school siege ended in a bloody shoot-out

DARFUR: WFP, STILL NO CONTACT WITH MISSING AID WORKERS

Sea views boost property market

The British do indeed love to be beside the seaside, it appears, with house prices on the coast outperforming other properties in the same region, according to a report.

U.N. wants Israeli pullout 'without delay'

The U.N. Security Council unanimously called for an Israeli withdrawal from Palestinian-controlled cities in the West Bank "without delay" Thursday as the White House said it would send Secretary of State Colin Powell to the region in a bid to end the conflict.