PRESENTATA ALLA VOLVO TRIBUZI DI SAN BENEDETTO DEL TRONTO LA NUOVA MOTORIZAZZIONE DIESEL DELLA SUV SVEDESE
PROVATA ALLA OPEL NARDI'S CAR DI ASCOLI PICENO LA VERSIONE STATION DELLA BERLINA TEDESCA
Cavallaro S, D'Agata V, Alessi E, Coffa S, Alkon DL, Manickam P, Ciotti MT, Possenti R, Bonini P, Marlier L, Calissano P.
Fanconi anaemia (FA) is a rare genetic cancer-susceptibility syndrome that is characterized by congenital abnormalities, bone-marrow failure and cellular sensitivity to DNA crosslinking agents. Seven FA-associated genes have recently been cloned, and their products were found to interact with well-known DNA-damage-response proteins, including BRCA1, ATM and NBS1. The FA proteins could therefore be involved in the cell-cycle checkpoint and DNA-repair pathways. Recent studies implicate the FA proteins in the process of repairing chromosome defects that occur during homologous recombination, and disruption of the FA genes results in chromosome instability ”€ a common feature of many human cancers.